Summary The Copernican system was condemned as heretical by a decree of the Roman Inquisition in 1633. This decree was effectively, though not officially, withdrawn in 1757, after which date Catholic astronomers felt themselves free to accept and propagate the system without reserve. Between these dates their attitudes varied greatly. In France the decree was never promulgated and was legally unenforceable. Astronomers could be Copernican without any fear of consequences and most of them were, though some, out of respect for (...) the Church, refrained from declaring themselves publicly. In Italy the possible risks were greater, but a few Copernican or near-Copernican works were published without hostile reactions. The ecclesiastical authorities were tolerant and made little positive effort to enforce conformity. By 1744, the system was being freely propagated in Rome itself. (shrink)

We consider embeddings of structures which preserve spectra: if g: M → S with S computable, then M should have the same Turing degree spectrum (as a structure) that g(M) has (as a relation on S). We show that the computable dense linear order L is universal for all countable linear orders under this notion of embedding, and we establish a similar result for the computable random graph G. Such structures are said to be spectrally universal. We use our results (...) to answer a question of Goncharov, and also to characterize the possible spectra of structures as precisely the spectra of unary relations on G. Finally, we consider the extent to which all spectra of unary relations on the structure L may be realized by such embeddings, offering partial results and building the first known example of a structure whose spectrum contains precisely those degrees c with c′ ≥T 0″. (shrink)

Patients have received experimental pharmaceuticals outside of clinical trials for decades. There are no industry-wide best practices, and many companies that have granted compassionate use, or ‘preapproval’, access to their investigational products have done so without fanfare and without divulging the process or grounds on which decisions were made. The number of compassionate use requests has increased over time. Driving the demand are new treatments for serious unmet medical needs; patient advocacy groups pressing for access to emerging treatments; internet platforms (...) enabling broad awareness of compelling cases or novel drugs and a lack of trust among some that the pharmaceutical industry and/or the FDA have patients’ best interests in mind. High-profile cases in the media have highlighted the gap between patient expectations for compassionate use and company utilisation of fair processes to adjudicate requests. With many pharmaceutical manufacturers, patient groups, healthcare providers and policy analysts unhappy with the inequities of the status quo, fairer and more ethical management of compassionate use requests was needed. This paper reports on a novel collaboration between a pharmaceutical company and an academic medical ethics department that led to the formation of the Compassionate Use Advisory Committee. Comprising medical experts, bioethicists and patient representatives, CompAC established an ethical framework for the allocation of a scarce investigational oncology agent to single patients requesting non-trial access. This is the first account of how the committee was formed and how it built an ethical framework and put it into practice. (shrink)

How can the Father, the Son, and the Holy Spirit be distinct and yet identical? Prompted by the doctrine of the divine Trinity, this question sparked centuries of lively debate. In the current context of renewed interest in Trinitarian theology, Russell L. Friedman provides the first survey of the scholastic discussion of the Trinity in the 100-year period stretching from Thomas Aquinas' earliest works to William Ockham's death. Tracing two central issues - the attempt to explain how the three (...) persons are distinct from each other but identical as God, and the application to the Trinity of a 'psychological model', on which the Son is a mental word or concept, and the Holy Spirit is love - this volume offers a broad overview of Trinitarian thought in the thirteenth and fourteenth centuries, along with focused studies of the Trinitarian ideas of many of the period's most important theologians. (shrink)

Historians of seventeenth-century science have frequently asserted that Kepler's laws of planetary motion were largely ignored between the time of their first publication and the publication of Newton's Principia . In fact, however, they were more widely known and accepted than has been generally recognized.Kepler's ideas were, indeed, rather slow in establishing themselves, and until about 1630 there are few references to them in the literature of the time. But from then onwards, interest in them increased fairly rapidly. In particular, (...) the principle of elliptical orbits had been accepted by most of the leading astronomers in France before 1645 and in England by about 1655. It also received quite strong support in Holland.The second law had a more chequered history. It was enunciated in its exact form by a few writers and was used in practice by some others without being explicitly formulated, but the majority, especially after 1645, preferred one or another of several variant forms which were easier to use but only approximately correct. The third law attracted less interest than the others, chiefly perhaps because it had no satisfactory theoretical basis, but it was correctly stated by at least six writers during the period under review.Between about 1630 and 1650 Kepler's Epitome Astronomiae Copernicanae was probably the most widely read work on theoretical astronomy in northern and western Europe, while his Rudolphine Tables, which were based upon the first two laws, were regarded by the majority of astronomers as the most accurate planetary tables available.Kepler's work certainly did not receive all the recognition it deserved, but the extent to which it was neglected has been much exaggerated. (shrink)

The nub of Sherlock Holmes's investigative process has been overlooked in the analytical literature on the subject—until now. This study drills down into the character's methodology to explicate what is at its very heart. I present Holmes as a rational empiricist operating at the explicit level of observation and inference but also as an intuitive empathizer operating at a tacit level of awareness involving imaginative guesswork. I claim that the operational story of the former, where identifying essential clues to resolving (...) a case involves intuitively sensing relevance, necessarily relies on that of the latter. (shrink)